Eosinophils of Blood During Prolonged Exposure to Cold and Chronic Administration of Cortisone Acetate.

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Abstract
Circulating eosinophils were countered in blood samples from rats exposed to cold for 90 days, and from rats treated with diverse doses of cortisone acetate. The eosinophils decreased 86% within 6 hrs. after exposure to a temp. of 2[degree]C but returned to above normal values within 48 hrs. and remained high for the duration of the 90-day exposure period. In spite of continued exposure, the eosinophils showed a diurnal rhythm and were sensitive to exogenous cortisone acetate. Normal rats required a daily dose of 100 [mu]g cortisone acetate to maintain a depressed level of eosinophils for 21 days. It is suggested that a eucorticoid state may develop during adaptation to cold.