INDUCTION OF ESTROUS BEHAVIOR IN ANESTROUS CATS WITH THE FOLLICLE-STIMULATING AND LUTEINIZING HORMONES OF THE ANTERIOR PITUITARY GLAND

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Abstract
Five of 6 young adult anestrous cats came into heat within 7 to 13 days after being injected daily with a highly purified extract of the ant. pituitary gland containing follicle-stimulating hormone (FSH) with traces of luteinizing hormone (LH). The total dosage used in each instance was 22, 34, 52. 77, 84 and 109 rat units of follicle-stimulating hormone. The cat which received 109 units for 16 days did not come into heat, and when autopsied was found to be a surgical castrate. The behavior of the estrous cats before, during and after mating was identical in every respect with the behavior of cats which come into heat spontaneously. The ovaries of these cats contained normal estrous follicles. Ovulation had occurred in 2 of the ovaries, and extensive luteinization of follicles without ovulation was also noted. A highly purified fraction of follicle-stimulating hormone containing traces of luteinizing hormone induced estrous behavior in anestrous cats probably by means of ovarian stimulation.