Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.
- 1 November 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (21) , 8161-8165
- https://doi.org/10.1073/pnas.85.21.8161
Abstract
A variable region (V.delta.5) of the T-cell receptor (TcR) .delta. chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobase 3'' of the constant region (C.delta.) element. The V.delta.5 coding sequence is in a transcriptional orientation opposite the J.delta. (joining region) and C.delta. coding elements and rearranges by inversion. The C.delta. is divided into four exons, three of which encode amino acids of TcR .delta. polypeptide, and the fourth comprises the entire 3'' untranslated region. In this respect, C.delta. resembles C.alpha. rather than C.beta. or C.gamma.This publication has 27 references indexed in Scilit:
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