Effects of Aldosterone on Contractile and Electrical Properties of Driven Isolated Rabbit Atria.

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Abstract
Summary The effects of aldosterone on contractile and electrical properties of driven, isolated rabbit atrial preparations have been determined. Very low concentrations (e.g., 10-10M) failed to produce significant effects on contractile force, excitability, effective refractory period, or diastolic tension. Higher concentrations of both the d,l and d-form tended to produce a slight negative inotropic effect except at a d,l-aldosterone concentration of 1.7 × 10-6M, where the normal decrease in contractile force was slightly delayed compared to control preparations. These higher concentrations also had no significant action on electrical parameters compared to appropriate controls.