The metabolism of 2:3-, 2:6- and 3:5-dichloronitrobenzene and the formation of a mercapturic acid from 2:3:4:5-tetrachloronitrobenzene in the rabbit

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Abstract
The main products excreted were phenols, conjugated with glucuronic and sulfuric acids, and dichloroanilines. No mercapturic acids were detected in the urines. Several nitro- and amino-dichloro-phenols were identified. A small amount of a catechol derivative is probably formed from 2:6-dichloronitrobenzene. 3:5:3[image]:5[image]-Tetra-chloroazoxybenzene was isolated from the urine of rabbits given 3:5-dichloronitrobenzene. A mercapturic acid, probably N-acety)-S-(2:3:4-trichloro-6-nitrophenyl)-L-cysteine, was isolated from the urine of rabbits given 2:3:4:5-tetrachloronitrobenzene. The chief features of the metabolism of the 19 chloromononitrobenzenes are summarized and discussed.

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