IMMUNOGLOBULIN-SYNTHESIS BY AN SV-40-INDUCED HAMSTER LYMPHOMA

  • 1 January 1976
    • journal article
    • research article
    • Vol. 31  (3) , 495-502
Abstract
A transplantable lymphoid tumor induced in Syrian hamsters by SV-40 was shown to synthesize a 7S.gamma.2 monoclonal immunoglobulin [Ig] which was detectable in the serum of tumor bearing hamsters. Monoclonal Ig of the same idiotype was also found in the membrane of the tumor cell. The induction of Ig synthesizing tumors by SV-40 should be useful for studies on Ig synthesis, lymphoid cell receptors and tumor immunity.