Mixed Infections with Coxsackie and Lansing Poliomyelitis Viruses in Mice.

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Abstract
In the presence of the Lansing poliomyelitis virus infection, the virulence of the Ohio-R strain of C virus for 4-week-old white Swiss mice (otherwise insusceptible) seemed to be enhanced. The Nancy strain of C virus had a noticeable effect on the patho-genesis of the Lansing infection in 4-week-old mice. The frequency with which the forelimbs became paralyzed first as compared with the first appearance of hindlimb paralysis was influenced by the presence of Nancy virus in the higher levels of the CNS. The presence of Nancy virus in the lumbar region of the spinal cord, following intraspinal inoculation, seemed to limit extension of the Lansing virus thus altering the normal progress of this exptl. infection. There was no evidence of enhancement of the virulence of the Nancy virus in the presence of the Lansing infection. In addition to exerting a sparing effect on the Lansing infection, animals which had received a previous intraspinal inoculation of Nancy virus survived twice as long as those which had received Lansing virus alone. The biphasic distribution of incubation periods generally observed among animals infected with Lansing virus was not evident among those animals which had received both viruses.