Influence of the Thyroid Gland on Jejunal Secretion in the Dog

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Abstract
Hyperthyroidism, as evidenced by an increased B. M. R., usually stimulates the secretory activity (vol. and invertase outputs) of jejunal fistulae in fasted dogs. This stimulation may be induced by either thyroxine or desicccated thyroid. Hypo-thyroidism, whether induced by propyl thiouracil feeding or by thyroidectomy, depresses jejunal secretory activity. No striking differences were observed between the effects of thyroxine and desiccated thyroid; nor did propyl thiouracil differ significantly from thyroidectomy in its effects. These effects were observed in both innervated and denervated fistulae , indicating that extrinsic nerve pathways are not involved. The immediate effect of propyl thiouracil ingestion is an increased vol. output. The detn. of B. M. R. under Na Pentothal anesthesia is highly satisfactory for use in the dog.

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