CHLORIDE, CARBOHYDRATE AND WATER METABOLISM IN ADRENAL INSUFFICIENCY AND OTHER CONDITIONS

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Abstract
Exps. show that the water content of the muscle in cats progressively increases after adrenal removal while the chloride concn. in the tissue falls. Hepatic water and chlorides follow the same course, and serum water and chlorides slowly though steadily fall. Water and chloride metabolism during starvation shows marked similarity to that in adrenal insufficiency. A significant difference is the maintenance of a normal serum chloride level by the fasting animal, whereas the chloride concn. in adrenalectomized animals showing more or less severe symptoms of insufficiency is characteristically low. No correlation has been found between tissue chlorides and carbohydrates with one exception, i.e., after pancreatec-tomy the serum glucose and chloride levels reciprocally vary. Many experimental procedures reproduce the condition of muscle and liver hydration noted after adrenal removal, and it is possible also to induce and maintain low chloride and high water levels in the tissues without prejudice to the well-being of the animal. The changes in water and chloride balance noted after adrenalectomy do not appear to be specifically related to the absence of the cortical hormone.

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