Intercellular hormones

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Abstract
An investigation was made of the role of nucleotides and nucleosides in the increased proliferation-promoting activity of cell-free suspension fluids from cells slowly damaged by lethal radiation (I) as compared with similar fluids from undamaged cells (II). The nucleotide-N and nucleoside- and free purine-N contents of I were respectively about 34 and 5 times those of II. Nucleotides isolated from I, when combined with amino-acids and B-factors found in I, duplicated the proliferation-promoting effect of I. The nucleotide and nucleoside fractions consisted principally of adenine and guanine derivatives. Spec-troscopic evidence indicated a synthesis of materials absorb-ing at 2600 A. within the living, injured cells during the course of injury.

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