ALTERED SULFOBROMOPHTHALEIN METABOLISM IN MAN INDUCED BY ANTIFUNGAL AGENT X-5079C

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Abstract
Administration of the antifungal agent X-5079C to 28 patients with systemic fungous disease was associated with an abrupt and substantial rise in sulfobromophthalein retention soon after the start of treatment. Sulfobromophthalein retention was sustained throughout treatment, but fell promptly to normal after cessation of the administration of the drug. Lesser degrees of abnormality were observed in conjugated and unconjugated bilirubin values and some other liver function tests. Microscopic studies of liver sections from 14 patients showed the presence of periportal inflammation which disappeared after treatment was discontinued.