The role of aortic chemoreceptors during acute anemia

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Abstract
The importance of aortic chemoreceptors in the circulatory and metabolic responses during acute anemia was studied in anesthetized dogs. Data were obtained from nine dogs in which the aortic chemoreceptors were surgically denervated prior to induction of anemia, and from seven sham-operated dogs. Cardiac output , limb blood flow , limb and whole body oxygen uptake were determined at normal hematocrit (Hct) and at 30 min of anemia (Hct = 13%) produced by isovolemic dextran-for-blood exchange. At 30 min of anemia, was increased from 91 to 186 mL∙kg−1∙min−1 (p < 0.01) and from 99 to 153 mL∙kg−1∙min−1 (p < 0.01) in the sham and denervated groups, respectively. The increase in during anemia was less (p < 0.05) in the aortic-denervated series. Limb flow was also increased during anemia in both groups (p < 0.01); the mean value of 89 mL∙kg−1∙min−1 in the denervated group was less than that of 130 mL∙kg−1∙min−1 observed in the sham animals (p < 0.05). Whole body decreased (p < 0.05) in the denervated group at 30 min of anemia; limb was maintained at the preanemic control value in both groups. The data indicate that during acute anemia the aortic chemoreceptors contribute to the increase in .