An Evaluation of the131I-Triiodothyronine Resin Sponge Test

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Abstract
The uptake of 131I-triiodothyronine by a resin sponge and by the red cells has been determined in a series of 50 hyperthyroid, 50 hypothyroid and 50 euthyroid individuals. The results of the 2 tests were found to be comparable. Variation in the time of incubation showed that the uptake of 131I-triiodothyronine by the resin sponge increased in a linear fashion when plotted against the logarithm of time. The rate at which 131I-triiodothyronine was taken up by the resin increased as the concentration of thyroxine in serum was increased. Modification of the washing procedure showed that the binding of triiodothyronine by the resin has 2 phases, one in reversible equilibrium, the other of an irreversible nature. It is concluded that the resin sponge method is a measure of the speed with which triiodothyronine becomes bound by the resin. It depends ultimately on the number of binding sites on the serum proteins able to bind triiodothyronine, in which respect it is similar to the red cell method

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