Studies on antiatherosclerotic agents. IX. Synthesis of 7-ethoxycarbonyl-4-hydroxymethyl-6,8-dimethyl-1(2H)-phthalazinone (EG 626).

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Abstract
To enhance the biostability of the ester linkage of 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone, which has potent biological activities, the corresponding tert-butyl ester and 7-ethoxycarbonyl-4-hydroxymethyl-6,8-dimethyl-1(2H)-phthalazinone (EG 626) were prepared. The synthesis and inhibitory effects on platelet aggregation and edematous arterial reaction of these and other closely related compounds were investigated in rabbits. EG 626 appears to be a potentially effective antithrombotic and antiatherosclerotic agent.