Comparative Study of Alterations Induced by 7,12-Dimethylbenz[α]anthracene and Polymer Films in the Subcutaneous Connective Tissue of Rats2

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Abstract
Alterations occurring before tumor forminced cellophane films only were immation in rat tissue around subcuta-planted in control animals. A number neously implanted pellets containing of morphological and histochemical 7,12-dimethylbenz[α]anthracene and methods were used, including reactions cellophane films were compared. Pelfor: various oxidative enzymes, protein lets consisting of paraffin wax and groups, polysaccharides, lipides, nucleic acids, etc. Characteristic alterations induced by both carcinogenic agents, polycyclic hydrocarbon and polymer film, included: 1) various manifestations of injury to fibroblasts, 2) extensive, long-lasting, and distorted processes of fibrogenesis, and 3) accumulation of cells with morphological and histochemical characteristics of immature fibroblasts. Possible mechanisms of sarcoma development in the subcutaneous connective tissue of rats are discussed, and the role of distorted fibrogenesis combined with proliferation of fibroblasts is stressed.