RELATIVE DURATION OF ACTION OF NATURAL AND SYNTHETIC ESTROGENS ADMINISTERED PARENTERALLY IN WOMEN WITH ESTROGEN DEFICIENCY

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Abstract
The duration of action of various estrogen prepns. was studied. The method employed was to administer by injn. a standard total dosage of 20 mg. of each estrogen to women who had been castrated or who suffered from ovarian agenesis, but whose uteri remained intact. The duration of the time interval between the last injn. and the onset of withdrawal bleeding was then observed. The estrogens which were tested are listed in the order of increasing duration of action. Those with shortest action, as shown by shortest interval between last injn. and onset of bleeding are listed first, viz.: estradiol 3-benzoate, estradiol 3-furoate, diethylstilbestrol dipropionate and diacetate, in oil soln.; estradiol dipropionate in oil soln.; estradiol 17-caprylate and estradiol 3-benzoate 17 n-butyrate, in oil soln.; diethylstilbestrol n-dibutyrate in oil soln., diethylstilbestrol difuroate in small-crystal oil suspension; estradiol 3-benzoate in aqueous emulsion; estradiol 3-benzoate in microcrystalline aqueous suspension and diethylstilbestrol difuroate in large crystal oil suspension.

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