The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—II: A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

This publication has 14 references indexed in Scilit:

• The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I
  Biochemical Pharmacology, 1992
• Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2)
  Biochemical Pharmacology, 1992
• DT-diaphorase and cancer chemotherapy
  Biochemical Pharmacology, 1992
• The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954: Exceptional frequency and stability of the crosslink
  Biochemical Pharmacology, 1992
• Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species
  Biochemical Pharmacology, 1991
• Cytotoxicity and activation of CB1954 in a human tumour cell line
  Biochemical Pharmacology, 1991
• A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells
  Biochemical Pharmacology, 1988
• CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells
  Biochemical and Biophysical Research Communications, 1986
• Serum-mediated Immunological Non-reactivity between Histoincompatible Cells in Tetraparental Mice
  Nature, 1971
• 2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256
  Biochemical Pharmacology, 1969