Inhibition of Catalase Activity by Isoniazid and the Effect of Vitamin B6.

1 January 1963

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 112 (1) , 30-33
https://doi.org/10.3181/00379727-112-27941

Abstract

The inhibition by INH of mammalian catalase and mycobacterial catalase of representative strains was markedly enhanced by divalent copper ions. Pyridoxal hydrochloride completely reversed the inhibitory action of the INH-Cu⁺⁺ complex. This antagonism apparently was due to chemical removal of the inhibitor by precipitation. Pyridoxamine and pyridoxine, which respectively have slight and no effect in vitro against the antituberculosis activity of INH, did not significantly affect the INH-metal ion inhibition of mycobacterial catalase.

Keywords

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