Alteration of Renal Response to Carbonic Anhydrase Inhibitor by Synthetic Adrenal Steroids

Publisher Website
Google Scholar
Abstract
The increased urinary Na+ output induced by Diamox in water-loaded adrenalectomized rats was partially antagonized by the mineralocorticoid, desoxycorticosterone glucoside (DCG), the increased K+ excretion was augmented and urine volume was not affected. Intact rats subjected to the same treatment showed only a small, but significant, rise in K+ excretion. Under the same conditions, the glucocorticoid, hydrocortisone hemisuccinate (compound FH), significantly elevated Na+, K+ and H2O excretion in adrenalectomized rats receiving Diamox; intact rats showed an increase in Na+ and H2O excretion with no significant change in K+ output. Of particular interest is the finding that 2.5 mg compound FH alone increased H2O excretion in adrenalectomized rats to a slightly greater extent than Diamox alone with considerably less Na+ loss.