METABOLISM OF 4-C14-CORTISOL IN MAN: BODY DISTRIBUTION AND RATES OF CONJUGATION*†

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Abstract
The dynamics of cortisol metabolism in normal men at levels ordinarily maintained by endogenous sources has been only partly explored. Hellman et al. (1) have recently presented data on the rate and routes of excretion of 4-C14-cortisol in 2 patients with breast cancer, 1 with chronic lymphatic leukemia and 1 with multiple benign lipomata. Over 90 per cent of the radioactivity administered was excreted in the urine and feces in seventy-two hours. Little or no radioactivity was found in the exhaled carbon dioxide of these patients. In addition, the dynamic behavior of 4-C14-cortisol in an adrenalectomized oophorectomized patient was studied when the subject was untreated and when she was maintained on fairly large doses of intravenous cortisol. Peterson et al.