OBSERVATIONS ON SHOCK FOLLOWING BILATERAL VENOUS OCCLUSION OF THE HIND-LIMBS OF THE DOG

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Abstract
Bilateral venous occlusion of the hind-limb of the dog by means of ligation and lampblack injn. leads to a consistently fatal and rapid shock-like state. Early fluid adm. (NaCl or plasma) demonstrated to be effective in preventing this state in unilateral venous occlusion expts. is without beneficial action in these animals. Likewise, application of a rigid cast to both hind limbs and lower abdomen, in order to minimize fluid leakage into the injured area, is accompanied by slightly increased length of life but does not prevent the ultimate fatal result; this suggests that some other factor, perhaps a humoral "toxic" substance plays a role. The mechanisms and possible interpretation of these results are discussed.

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