QUANTITATIVE ASSESSMENT OF THE EFFECTS OF PLATELET DEPLETION IN THE AUTOLOGOUS PHASE OF NEPHROTOXIC SERUM NEPHRITIS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 36  (1) , 90-96
Abstract
The effects of platelet depletion with antibody were studied in 2 models of the autologous phase of nephrotoxic nephritis in the rabbit. In the telescoped model (animals pre-immunized to sheep Ig[immunoglobulin]G injected with sheep nephrotoxic antibody), platelet depletion did not alter intraglomerular fibrin deposition or evidence of glomerular damage but did significantly reduce proteinuria during the first 3 days of the 5 day experiment. In the passive model (animals injected with hyperimmune rabbit antiserum to sheep IgG 48 h after sheep nephrotoxic antibody and killed 3 h later), platelet depletion was associated with significantly fewer intraglomerular polymorphonuclear leukocytes (PMN) but again did not alter intraglomerular fibrin deposition. Platelets are apparently involved in the initiation of glomerular PMN localization in the autologous phase but fibrin-induced glomerular injury is platelet-independent.