The Role of Choline in the Turnover of Phospholipids
Open Access
- 1 May 1958
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 6 (3) , 235-241
- https://doi.org/10.1093/ajcn/6.3.235
Abstract
The effect of choline and choline deficiency on liver phosphatide metabolism has been studied in various species. Evidence to date indicates that a single dose of choline administered to choline-deficient animals increases the oxidation of liver fat as well as the synthesis of liver phosphatide P32. On the other hand, the addition of choline to liver slices derived from choline-deficient animals promotes the incorporation of P32 into the phosphatide molecules without stimulating fat oxidation. In addition, it was observed that in the rabbit and dog the rate of incorporation of P32 into liver phosphatides is greater during periods of choline deficiency than during daily supplementation of the diet with 1 per cent choline. The implications of these findings are discussed in reference to the mechanism whereby choline prevents or cures fatty livers.Keywords
This publication has 10 references indexed in Scilit:
- Role of Choline in the Hepatic Oxidation of FatThe American Journal of Clinical Nutrition, 1958
- Effect of Choline on Phosphatide Metabolism of Gholine-Deficient and Cholestero-Fed Rabbits.Experimental Biology and Medicine, 1956
- Choline Deficiency in the RabbitJournal of Nutrition, 1954
- Relation of Choline Oxidase Activity to Dietary Fatty LiversAmerican Journal of Physiology-Legacy Content, 1953
- The role of the liver and the kidneys in the maintenance of the level of free choline in plasmaThe Journal of Physiology, 1953
- The Effects of Choline and Methionine on Phospholipide Formation in Patients with Liver Disease as Measured by Radioactive PhosphorusScience, 1949
- THE EFFECT OF INGESTED CHOLINE ON THE TURNOVER OF PLASMA PHOSPHOLIPIDSPublished by Elsevier ,1945
- RADIOACTIVE PHOSPHORUS AS AN INDICATOR OF PHOSPHOLIPID METABOLISMPublished by Elsevier ,1939
- The effects of the components of lecithine upon deposition of fat in the liverThe Journal of Physiology, 1932
- The effect of lecithine on fat deposition in the liver of the normal ratThe Journal of Physiology, 1932