Effects of Hemorrhage on Blood Pressure Responses to Epinephrine and to Histamine

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Abstract
Effects of hemorrhage on blood pressure responses to epinephrine and to histamine were studied in dogs anesthetized with sodium pentobarbital. A series of graded doses of either l-epinephrine bitartrate or l-histamine diphosphate was given before and after hemorrhage, and the blood pressure effects of each dose of the administered drug were recorded. Amount of hemorrhage was determined as 10% of the experimental animal's Evans blue blood volume. Blood pressure records were analyzed in terms of minimum or maximum blood pressure attained, actual rise or actual fall in blood pressure and duration of primary blood pressure response before and after hemorrhage. The results showed that there is a significant change in the minimum and maximum blood pressures attained, but no significant change in the actual rise, actual fall or duration of primary response of blood pressure. The amount of change in minimum or maximum attainable blood pressure was directly related to the amount of change in blood pressure which resulted from the decrease in blood volume.