Effect of Indapamide on Blood Pressure in Patients with Essential Hypertension: Preliminary Results of a Multicentre Study

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Abstract
A single-blind, multicentre trial was carried out in 251 patients with essential hypertension to assess the effectiveness and tolerance of treatment with indapamide. After a 2-week period on placebo, patients received 2.5 mg indapamide daily, as a single dose, for a further 2 months. The results showed that there was little change in blood pressures after placebo but a significant reduction in systolic and diastolic blood pressure, both in supine and standing positions, after indapamide. Adequate blood pressure control was achieved with indapamide alone in 63 % of the 138 patients with mild hypertension, and in 52% of those with moderate hypertension. Non-limiting side-effects were observed in only 7 patients, and there were no significant biochemical changes except for a statistically significant but slight decrease in sodium, potassium, chloride, and calcium levels.

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