EFFECT OF 20, 60 AND 120 MINUTES OF RENAL ISCHEMIA ON GLOMERULAR AND TUBULAR FUNCTION

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Abstract
Dogs were subjected to renal ischemia by clamping the renal arteries for periods varying from 20 min. to 2 hr., and the effects on renal function were studied by observations of renal plasma flow and of the completeness with which p-amino hip-purate (PAH) and creatinine were extracted from the renal plasma during 2 hr. after removal of the clamps. Renal blood flow was quickly resumed at a nearly pre-ischemic rate. The proportions of PAH and creatinine extracted from the plasma were not markedly affected after 20-min. ischemia, but after 2-hr. ischemia they were reduced: the creatinine extraction, in 3 expts., to 63, 26, and 9%, respectively, of preischemic values, the PAH extraction, in 4 expts., to 37,14,11, and 10%, respectively. With tubular injury such as that caused by ischemia, PAH clearance does not serve as a measure of renal blood flow; it appears doubtful that in the presence of such injury clearances of creatinine and similarly diffusible substances can be interpreted as measures of glomerular filtration rate.

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