Effect on kidney S35O4 uptake of compounds related to SO4 transport and metabolism

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Abstract
Experiments have been carried out to test the effects on S35O4 accumulation by rat kidney cortex slices in vitro of 1) compounds known to affect renal SO4 reabsorption (thiosulfate, amino acids); 2) compounds secreted by the kidney, or known to affect specific cellular transport systems (including tetraethylammonium ions, guanidine, creatinine, carinamide, probenecid, phloretin, diethylstilbestrol, ethylenediaminetetraacetate sodium); and 3) compounds related to SO4 metabolism (aryl sulfatase substrates). Under the conditions of the experiment, net S35O4 uptake was depressed by thiosulfate, certain amino acids, carinamide, phloretin, diethylstilbestrol, and aryl sulfatase substrates. It was enhanced by ethylenediaminetetraacetate sodium. Other compounds were without effect. These results are discussed from the point of view of the possible relationship between SO4 accumulation in vitro and transport in vivo.