Bone Healing in Lysine-Deficient Rats

Abstract
Retarded epiphyseal growth results from lysine deficiency and starvation, but there is no appreciable interference with the healing of bone. The effects of lysine deficiency are similar to those that occur with restricted food intake and include steady weight loss, retarded skeletal and visceral growth and atrophy of subcutaneous fat and muscles. Increasing the dietary lysine from 1 to 3% has no effect on either growth or bone healing. A method for producing uniform lesions in bone for purposes of making comparative studies of healing has been described.
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