EFFECT OF ADRENAL CORTICAL EXTRACT AND CERTAINSTEROID HORMONES ON THE RESPONSE OFADRENALECTOMIZED RATS TO INTRAPERITONEALINJECTIONS OF AN ISOTONIC GLUCOSE SOLUTION

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Abstract
The effect of cortical extracts, desoxycorticosterone acetate (DCA), progesterone, testosterone propionate, and estradiol dipropionate upon the fluid and electrolyte transfer, and on the protection afforded against the appearance of fatal circulatory collapse, following the intrap. inj. of a 5.5% glucose soln., was tested on 120 adrenalectomized rats. Two factors, not wholly interdependent, must be recognized in the response to glucose inj. One has to do with ability of animal to transfer fluid and electrolytes from the interstitial fluid stores into the ascitic fluid, via the plasma, which factor could not be corrected by any type of therapy used. The second concerns the development of a progressive circulatory failure, which could be prevented by either cortical extract or DCA. The latter showed about 1/9 the activity of the extract. There was no evidence that the action of DCA was qualitatively dissimilar to that of cortical extract.