THE EFFECT OF PRIMING DOSES OF DESOXYCORTICOSTERONE ACETATE IN PREVENTING CIRCULATORY FAILURE AND SHOCK IN THE ADRENALECTOMIZED DOG

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Abstract
The effectiveness of D.CA. (desoxycorticosterone acetate) in protecting the adrenalectomized dog against circulatory failure and shock following the intraperit. inj. of an isotonic glucose soln., intraven. inj. of massive doses of epinephrine, trauma to hind leg muscles, and intestinal manipulation was tested in 28 animals. D.C.A. protected against "glucose" and muscle trauma shock as effectively as did cortical extract. Protection against epinephrine shock, while present, was not as effective as with cortical extract. No protection was observed against the circulatory collapse following intestinal stripping, death following in a time period similar to that seen in adrenalectomized untreated controls. Unusual symptoms were often present in the intestinal stripped dogs which were quite alien to those of shock and which are attributed to the large dosage of D.CA. used.