GOITER AND MYXEDEMA DUE TO IODIDE ADMINISTRATION

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Abstract
Four cases of myxedema due to KI administra tion were observed in one clinic over a relatively brief period; 3 of the patients also developed a clinically discernable goiter. Failure to recognize the iatrogenic nature of the syndrome led to an unnecessary subtotal thyroidectomy in one patient. In all instances, thyroid function increased rapidly when iodides were discontinued. Two patients developed a mild hyperthyroid state at this time, and in one, this was associated with a dramatic decline in cardiopulmonary status leading to his demise. It is believed that iodide-induced thyroid abnormalities are more common than is generally appreciated.