Reduction Potentials of Imine-Substituted, Biologically Active Pyridines: Possible Relation To Activity
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 10 (3) , 185-192
- https://doi.org/10.3109/10715769009149887
Abstract
Cyclic voltammetry data were obtained for a number of biologically active compounds which incorporate imine substitution on the pyridine nucleus. The reductions in acid (iminium ion formation) were for the most part reversible, and in the range of—0.5 to—0.7 V. The toxic effect of these drugs is thought to be caused by the generation of reactive oxygen radicals that arise viacharge transfer, or by disruption of electron transport chains.Keywords
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