ANALYSIS OF THE BLOOD SUGAR RESPONSE OF OBESE-HYPERGLYCEMIC MICE AND NORMAL MICE TO HORMONES: GROWTH HORMONE,CORTISONE, AND CORTICOTROPIN1

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Abstract
INFORMATION on the effects of growth hormone, corticotropin (ACTH), or cortisone on the blood sugar of mice is scanty. Young (1938) found that an anterior pituitary extract which was diabetogenic in cats and dogs was without effect on the blood sugar when injected into mice. Westermeyer and Raben (1954) found that their oxycel preparation of corticotropin (Rabin et al., 1952) produced a fall in the blood sugar of Swiss mice after administration of doses of one to 300 μg. The decrease was significant after one-half hour and maximal after 3 hours. These investigators also found that larger doses of Armour growth hormone (0.1 mg. to 5.0 mg.) produced decreases in blood sugar of similar magnitude to those produced by corticotropin. In a systematic investigation of the biochemical and endocrine factors involved in the maintenance of hyperglycemic blood sugar levels in the obese-hyperglycemic mice, it was of importance to determine the effects of the diabetogenic hormones on the blood sugar of these animals.