NATURE OF ANTIGENIC COMPLEX RECOGNIZED BY LYMPHOCYTES-T .7. EVIDENCE FOR AN ASSOCIATION BETWEEN TNP-CONJUGATED MACROPHAGE MEMBRANE COMPONENTS AND IA ANTIGENS
- 1 January 1978
- journal article
- research article
- Vol. 121 (3) , 1152-1156
Abstract
The effects of antisera directed against guinea pig Ia [immune response associated] antigens on the ability of TNP[trinitrophenyl]-conjugated macrophages to stimulate TNP-specific T [thymus-derived] lymphocyte proliferation were studied. Treatment of macrophages with anti-Ia sera for 1 h before, 1 h immediately after or 24 h after TNP-modification resulted in a reduced ability to stimulate the TNP-specific T cell. The inhibition produced by anti-Ia sera was specific and did not result from interference with the ability of macrophages to process TNP-conjugated membrane antigens in a nonspecific manner. Brief treatment with anti-Ia serum did not result in inhibition of Ia-antigen synthesis nor could evidence of carry-over of anti-Ia antibody into the lymphocyte cultures be obtained. Anti-Ia sera interfere with the development of a TNP-specific immunogen on the macrophage surface. An association probably exists between TNP-modified membrane proteins and Ia antigens on the macrophage surface.This publication has 9 references indexed in Scilit:
- NATURE OF ANTIGENIC COMPLEX RECOGNIZED BY LYMPHOCYTES-T .6. EFFECT OF ANTI-TNP ANTIBODY ON T-CELL RESPONSES TO TNP-CONJUGATED MACROPHAGES1978
- Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complexThe Journal of Experimental Medicine, 1977
- Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.Proceedings of the National Academy of Sciences, 1977
- Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.The Journal of Experimental Medicine, 1977
- SPECIFIC BINDING OF T-LYMPHOCYTES TO MACROPHAGES .2. ROLE OF MACROPHAGE-ASSOCIATED ANTIGEN1977
- NATURE OF ANTIGENIC COMPLEX RECOGNIZED BY T-LYMPHOCYTES .4. INHIBITION OF ANTIGEN-SPECIFIC T-CELL PROLIFERATION BY ANTIBODIES TO STIMULATOR MACROPHAGE IA ANTIGENS1977
- RELATIONSHIP BETWEEN TRINITROPHENYL AND H-2 ANTIGENS ON TRINITROPHENYL-MODIFIED SPLEEN-CELLS .1. H-2 ANTIGENS ON CELLS TREATED WITH TRINITROBENZENE SULFONIC-ACID ARE DERIVATIZED1977
- EXPRESSION OF IA ANTIGENS ON IMMUNOCOMPETENT CELLS IN GUINEA-PIG .2. IA ANTIGENS ON MACROPHAGES1977
- Nature of the antigenic complex recognized by T lymphocytes. I. Analysis with an in vitro primary response to soluble protein antigens.The Journal of Experimental Medicine, 1976