Quantitative ultrastructural study of muscle satellite cells in Duchenne dystrophy
- 1 March 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 29 (3) , 401
- https://doi.org/10.1212/wnl.29.3.401
Abstract
Quantitative ultrastructural studies of satellite cell populations, and nuclear chromatin analysis of satellite cell nuclei and true subsarcolemmal nuclei were carried out in normal and Duchenne muscular dystrophy (DMD) muscles. There was a remarkable increase in the number of satellite cells in muscles of patients with mild to moderate stages of DMD, as compared to preclinical or very early and probably advanced stages of DMD, and a significant increase in euchromatin content was found in the satellite cell nuclei in DMD. Since it is generally accepted that satellite cells participate actively in muscle fiber regeneration, this study suggests that muscle fiber regeneration is ineffective in DMD.This publication has 6 references indexed in Scilit:
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- Duchenne Dystrophy: Alteration in Muscle Plasma Membrane StructureScience, 1977
- Electron Microscopic Study on the Satellite Cell in the Muscle of Duchenne Muscular DystrophyJournal of Neuropathology and Experimental Neurology, 1976
- REPRESSED AND ACTIVE CHROMATIN ISOLATED FROM INTERPHASE LYMPHOCYTESProceedings of the National Academy of Sciences, 1963
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