Relationship of Infectious Canine Hepatitis Virus to Human Adenovirus

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Abstract
The intranuclear inclusions provoked by a recent isolate of infectious canine hepatitis (ICH) virus in dog kidney cell culture resembled strikingly the inclusions found in adenovirus infections of human epithelial cell lines. The possibility of a closer relationship of ICH virus to the adenovirus group was investigated. Paired sera from patients with different adenovirus infections (type 3, 4, 7 and 14) showed an almost equal rise in complement-fixing antibodies whether they were tested with antigen prepared from known human adenoviruses or 3 different ICH virus strains. Therefore these viruses share the common complement-fixing antigen of the adenovirus group. In other respects ICH virus also would fit in this group (nonpathogenicity for the usual laboratory animals, resistance to ethyl ether, persistence after infection and some clinical manifestations in dogs).