Inhibition of gastric secretion by thyroid preparations
- 1 June 1959
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 196 (6) , 1262-1265
- https://doi.org/10.1152/ajplegacy.1959.196.6.1262
Abstract
Four dogs with Thomas gastric pouches and one dog with a Heidenhain pouch were stimulated to secrete gastric juice by feeding 100 gm of lean beef. Feeding whole desiccated thyroid ordinarily caused a significant fall in volume of gastric juice and in the total quantity of HCl secreted. Crystalline thyroxine yielded erratic results and one trial with triiodothyronine produced a significant increase in gastric secretion. Thyroidectomy in one dog resulted in a gradual decline in secretion, but hypothyroidism produced by administration of mercaptoimidazole in another animal lead to a significant increase in secretion.Keywords
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