THE INFLUENCE OF ORAL HYPOGLYCAEMIC AGENTS (CARBUTAMIDE AND TOLBUTAMIDE) ON THE SERUM PROTEINS OF NORMAL RATS

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Abstract
SUMMARY: The effect of prolonged administration of carbutamide and tolbutamide on serum proteins of normal rats has been investigated. Carbutamide, already known to produce an increase of thyroid weight and of serum cholesterol, caused disproteinaemia characterized by increase of total proteins and α1-globulin. Tolbutamide exerted no thyrostatic action and caused no changes in serum proteins. It is of interest that prolonged administration of water alone also induced an increase in α1-globulin but, unlike carbutamide, a decrease in γ-globulin. The changes of the serum proteins are discussed in relation to possible endocrine factors involved.