First selective lithiation of pyridylpiperazines: straightforward access to potent pharmacophores
- 2 April 2005
- journal article
- Published by Elsevier in Tetrahedron
- Vol. 61 (20) , 4761-4768
- https://doi.org/10.1016/j.tet.2005.03.026
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- 4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonistsBioorganic & Medicinal Chemistry Letters, 2005
- Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile DysfunctionJournal of Medicinal Chemistry, 2004
- Dopamine D4Ligands and Models of Receptor Activation: 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy TuningJournal of Medicinal Chemistry, 2004
- Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacyBioorganic & Medicinal Chemistry Letters, 2001
- Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid DimethylamideJournal of Medicinal Chemistry, 2001
- Sequential mono-N-arylation of piperazine nitrogens. Part 1: A simplified method and its application to the preparation of a key N,N′-biaryl piperazine antifungal intermediateTetrahedron Letters, 1999
- Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential mapsBioorganic & Medicinal Chemistry Letters, 1999
- Solution phase combinatorial synthesis of arylpiperazinesTetrahedron Letters, 1997
- Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazinesTetrahedron Letters, 1996
- Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine AnalogsJournal of Medicinal Chemistry, 1996