The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii
Open Access
- 31 January 2005
- journal article
- review article
- Published by Oxford University Press (OUP) in FEMS Microbiology Reviews
- Vol. 29 (1) , 65-81
- https://doi.org/10.1016/j.femsre.2004.07.001
Abstract
Type-IV secretion systems are devices present in a wide range of bacteria (including bacterial pathogens) that deliver macromolecules (proteins and single-strand-DNA) across kingdom barriers (as well as between bacteria and into the surroundings). The type-IV secretion systems were divided into two subgroups and Legionella pneumophila and Coxiella burnetii are the only two bacteria known today to utilize a type-IVB secretion system for pathogenesis. In this review we summarized the available information concerning the icm/dot type-IVB secretion systems by comparing the two bacteria that possess this system, the proteins components of their systems as well as the homology of proteins from type-IVB secretion systems to proteins from type-IVA secretion systems. In addition, the phenotypes associated with mutants in the L. pneumophila icm/dot genes, their relations to properties of specific Icm/Dot proteins as well as the protein substrates delivered by this system are described.Keywords
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