Oxygen Transport, Utilization and Storage in Rats Acclimated to Altitude at Different Temperatures

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Abstract
Oxygen transport, utilization and storage and related functions were studied in rats exposed to simulated altitude (18,000 ft.) at three different temperatures (5°, 24° and 36℃) for periods in excess of 3 months. Liver, heart, kidney and adrenal weights were altered only where thermal influences were involved. Adrenal weight in altitude-cold was greater than in cold alone. The oxygen transport function was normal in altitude-cold, but it was depressed in altitude-heat. Liver succinic dehydrogenase activity was elevated in all altitude groups, but more so in both the heat and cold. That of the adrenals was elevated most in the altitude-cold. Oxygen storage was unaffected by thermal factors. Submitted on April 18, 1958

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