Novel route to some biologically important compounds starting with a common chiral, bicyclic, fused lactone: enantioselective synthesis of (–)-boschnialactone and two antithrombotics
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 2969-2975
- https://doi.org/10.1039/p19910002969
Abstract
Three biologically important compounds, (–)-boschnialactone and the antithrombotics (+)- and (–)-(5Z)-6-{(1S, 4R)-3-endo-(4-chlorophenylsulphonylamino)bicyclo[2.2.1]hept-5-en-2-endo and exo-yl}hex-5-enoic acid have been synthesized starting from a common chiral lactone which is easily available via an asymmetric Diels–Alder reaction.Keywords
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