BACTERIOSTATIC EFFECTS OF HORSE SERA AND SERUM FRACTIONS ON CLOSTRIDIUM WELCHII TYPE A AND ABOLITION OF BACTERIOSTASIS BY IRON SALTS

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  • 1 January 1967
    • journal article
    • research article
    • Vol. 12  (3) , 285-+
Abstract
Under a variety of conditions of concentration, Eh, and pH, horse anti-Clostridium welchii serum and normal horse serum exerted similar bacteriostatic effects against C. welchii Type A. Ferric iron abolished the bacteriostatic effect when added during the first 2 hours of incubation at Eh + 60 mV. Ferrous iron abolished the bacteriostatic effect when added after 3 hours. Ferric iron abolished the bacteriostatic effect at - 140 mV. A mixture consisting of horse [beta]2-and gamma-globulins together with human transferrin exerted a bacteriostatic effect similar to that of whole serum. This system responded in the same way as whole serum to the addition of iron. A mixture of horse [beta]2- and gamma-globulins exerted an immediate bactericidal effect which could not be prevented by ferric iron.