NEUROMUSCULAR DISEASES ASSOCIATED WITH BENIGN MONOCLONAL GAMMOPATHY - STUDY OF CSF AND SERUM-PROTEINS BY ISOELECTRIC-FOCUSING

  • 1 January 1982
    • journal article
    • research article
    • Vol. 65  (2) , 154-159
Abstract
In > 1200 cases examined by isoelectric focusing of CSF and serum proteins, 4 patients had benign monoclonal gammopathy. These patients were affected by amyotrophic lateral sclerosis of bulbar onset, sensitive neuropathy of Thevenard type, myasthenia gravis and limb-girdle muscular dystrophy, respectively. The difficulty in relating the differences in the clinical features of these cases to a common physiopathological mechanism and the incidence of this finding (0.4% in 873 cases ranging from 21-60 yr of age) do not seem to suggest any pathogenetic relationship between benign monoclonal gammopathy and the different neurological disorders encountered in these patients.