BIOASSAY OF ANTIFUNGAL AGENT X-5079C IN SERUM OF PATIENTS

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Abstract
Bioassay of X-5079C by serum dilutions was unsuccessful because it requires large volumes of serum and because of the fungistatic action and decay of the antifungal agent in solution. By adaptation of the technique of placing impregnated discs on seeded agar, quantitative assays for the drug in serum are possible. The lower detectable limits of X-5079C are near 20 ug/ml of standard solution. This concentration is also detectable in serum. Serum concentrations above 11.0 ug/val have not been found in patients receiving the drug.