The effect of feeding cholesterol without fat on the plasma-lipids of the rabbit. The role of cholesterol in fat metabolism

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Abstract
Amorphous cholesterol fed in a watery suspension is well absorbed by rabbits and causes a rise in free and esterified cholesterol, phospholipids, and neutral fats of plasma 24 hrs. after ingestion. All plasma-lipids show a progressive increase during prolonged cholesterol feeding. Feeding amorphous cholesterol without added fat induces lipemia more rapidly and to higher levels. Cholesterol-fed animals show depletion of fat reserves in 3-12 wks. in spite of undiminished food intake; a higher concn. of neutral fat in the lymph than in the plasma; a decreased I value of the plasma phospholipid fatty acids; and an increase in the I value of the non-phospholipid fatty acids; suggesting the fatty acids of plasma-lipids were derived from mobilized depot fat. Free cholesterol probably acts as a plasma lipid regulator, and in turn is dependent on availability of acetate for synthesis.

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