Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequences
- 19 October 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 223 (1) , 138-142
- https://doi.org/10.1016/0014-5793(87)80524-0
Abstract
Two types of cDNA clones encoding human protein kinase C (PKC) were isolated from a spleen cDNA library using rabbit protein kinase C βI/βII cDNA as a hybridization probe. Nucleotide sequence analyses of these cDNA inserts revealed complete primary structures of two distinct types of human protein kinase C βI and βII which differ only in their C‐terminal 50 or 52 amino acid residues. It was concluded that there exist four distinct types of PKC, PKC α, βI, βII and γ, in human as well as rabbit, and that the corresponding sequences are strictly conserved among mammalian species.Keywords
This publication has 9 references indexed in Scilit:
- [30] Cloning and evolution of calcium-dependent protease, cDNA cloning of a novel family of calcium-binding proteinsPublished by Elsevier ,1987
- Tissue-specific expression of three distinct types of rabbit protein kinase CNature, 1987
- Two types of complementary DNAs of rat brain protein kinase CFEBS Letters, 1986
- Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling PathwaysScience, 1986
- The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester ReceptorScience, 1986
- Cloning and expression of multiple protein kinase C cDNAsCell, 1986
- Studies and Perspectives of Protein Kinase CScience, 1986
- Dideoxy sequencing method using denatured plasmid templatesAnalytical Biochemistry, 1986
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977