Lysis of Yeast Cell Walls Induced by 2-Deoxyglucose at Their Sites of Glucan Synthesis
- 1 March 1968
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 95 (3) , 1169-+
- https://doi.org/10.1128/jb.95.3.1169-1172.1968
Abstract
Six sites of 2-deoxyglucose (2DG)-induced lysis on 3 yeasts (Schizosaccharomyces pombe, Pichia farinosa, and Saccharo-myces cerevisiae) coincided with the regions of growth of their glucan layers. Identification of the glucan layer as the site of lysis suggests a mechanism of attack by 2DG or by its derivatives. The glucan layer grows by addition of glucose into internal breaks of polysaccharide molecules. 2DG inhibited resynthesis (insertion of glucose) of the broken glycosidic linkage.This publication has 11 references indexed in Scilit:
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