THE CYTOLYTIC EFFECT OF SAPONIN ON THE WALLS OF VESSELS

Publisher Website
Google Scholar
Abstract
When frog muscle is perfused with saponin or bile salts in frog Ringer, the permeability of the vessel walls is increased, and this results in an increased rate of edema formation. If the muscle is perfused with a soln. of Hb to which saponin or bile salts have been added, the Hb. which in the absence of the lysins remains in the vessels, escapes through the vessel walls and appears in the extravascular spaces. While these effects are being produced, the lysins disappear, in part, from the perfusion fluid, being taken up by the vessel walls and other tissue cells. Quantitative detns. of the rate of uptake of the lysins and of their effects on permeability show that the kinetics of the cytolytic process are similar to the kinetics of hemolytic processes. The quantities of saponin involved in producing these changes in permeability are such as would cover the walls of the vascular system of the muscle with a layer of lysin less than 10 molecules thick.

This publication has 3 references indexed in Scilit: