Correlation of biological activity and high-pressure liquid chromatographic retention index for a series of propranolol, barbiturate, and anthranilic acid analogs

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Abstract
The antiarrhythmic activity of propranolol analogs [in rabbit atrium], the inotropic activity of propranolol analogs, the antiinflammatory activity of anthranilic acids [in rat paw edema], the hypnotic activity of barbiturates and the inhibition of cell division by barbiturates were correlated with either octanol-water partition coefficients or with high-pressure liquid chromatographic retention indices. The retention index, which was a scale based on the relative retention of the drug and a series of C3-C23 2-ketoalkanes, gave higher correlations with biological activity than was found between octanol-water partition coefficients and biological activity. Only in the case of the anthranilic acids was the retention index found to give the lower correlation.